Buy Psychedelics Online
Psychedelics (serotonergic hallucinogens) are powerful psychoactive substances that alter perception and mood and affect numerous cognitive processes. They are generally consider physiologically safe and do not lead to dependence or addiction. Their origin predates written history and they were employ by early cultures in many socio cultural and ritual contexts.
After the virtually contemporaneous discovery of (5R,8R)-(+)-lysergic acid-N,N-diethylamide (LSD)-25 and the identification of serotonin in the brain, early research focus intensively on the possibility that LSD and other psychedelics had a serotonergic basis for their action. Today there is a consensus that psychedelics are agonists or partial agonists at brain serotonin 5-hydroxytryptamine 2A receptors, with particular importance on those express on apical dendrites of neocortical pyramidal cells in layer V. Several useful rodent models have been develop over the years to help unravel the neurochemical correlates of serotonin 5-hydroxytryptamine 2A receptor activation in the brain, and a variety of imaging techniques have been employed to identify key brain areas that are directly affect by psychedelics.
Recent and exciting developments in the field have occurs in clinical research, where several double-blind placebo-controlled phase 2 studies of psilocybin-assisted psychotherapy in patients with cancer-relate psychosocial distress have demonstrat unprecedent positive relief of anxiety and depression. Two small pilot studies of psilocybin-assist psychotherapy also have shown positive benefit in treating both alcohol and nicotine addiction.
Recently, blood oxygen level–dependent functional magnetic resonance imaging and magnetoencephalography have been employ for in vivo brain imaging in humans after administration of a psychedelic, and results indicate that intravenously administer psilocybin and LSD produce decreases in oscillatory power in areas of the brain’s default mode network.